Reset Therapeutics

Careers

Open Positions:

Research Associate / Senior Research Associate, Medicinal Chemistry

Senior Research Associate, In Vitro Biology

 

Research Associate / Senior Research Associate, Medicinal Chemistry

Job Code: 17-124
Position type: Full time
Required education: BS / MS / PhD Degree
Areas of expertise desired: Chemistry, Drug Discovery, Medicinal Chemist, Scientist, Laboratory, Organic Chemistry, Synthesis

About the Position

We are seeking hands-on highly talented and motivated scientists with strong knowledge in organic chemistry reactions and mechanisms to join our small molecule discovery team working on high value disease targets.  Primary responsibilities include the synthesis and optimization of novel compounds characterized by their ability to modify components of the circadian molecular clock and its outputs.

As a member of our drug discovery team, you will be a part of a highly collaborative and fast-paced, multi-disciplinary research environment, working closely with our team of biologists and medicinal chemists.

Responsibilities

  • Design, develop, and perform experiments. Develop experimental procedures based on published literature, adapt based on results and changing scientific priorities, clearly communicate experimental plans and results verbally and in writing
  • Responsible for route selection, multi-step synthesis, purification and analytical characterization of our new chemical entities
  • Participate in the design and setup of our chemistry labs
  • Keep up to date knowledge of novel chemistry literature and technology methodologies
  • Must be well-versed in best laboratory practices with a strong knowledge of safe laboratory procedures
  • Must possess good scientific problem-solving ability

Requirements

  • RA – BS or MS in Organic Chemistry, with 1-5 years of experience in synthetic organic chemistry
  • SRA – MS or PhD with extensive industry experience in Organic Chemistry with 5+ years industry experience in small molecule organic chemistry
  • Demonstrated record of productivity in synthetic organic chemistry research as evidenced by publications and/or patents
  • Demonstrated hands-on proficiency in heterocyclic, organometallic, and scale up chemistry
  • Working knowledge of analytical instrumentation (HPLC, LCMS, NMR) for purification and structural determination of small molecules is required
  • Good working knowledge of analytical and purification techniques
  • Proven ability to perform research independently
  • Excellent scientific problem-solving ability
  • Strong interpersonal and communication skills (both written and verbal)
  • Ability to work collaboratively in a team
  • Strong work ethic with good time management skills

Compensation and Benefits

You will appreciate a competitive compensation package including excellent benefits (medical, dental, vision, 401k, life/disability insurance and more). You will enjoy a challenging work environment, amazing colleagues and the ability to make a difference.

Send your resume to careers@resettherapeutics.com.

 

Senior Research Associate, In Vitro Biology

Job Code: 17-125
Position type: Full time
Required education: BS Degree
Areas of expertise desired: Biochemical Assays and Screening

About the Position

We are seeking a Senior Research Associate with significant experience in industrial pharmaceutical screening to help drive its drug discovery programs. The primary responsibility of this position is the implementation and performance of biochemical and cell-based assays for the robust screening of compounds. The successful candidate will join a team of scientists to assess novel therapeutics targeting protein constituents of the circadian molecular clock and its outputs.

Responsibilities

  • Work closely with other members of the Molecular Pharmacology team to develop and optimize target-based screening assays
  • Perform robust target-based screening of compounds to determine the potency of test compounds
  • Work closely with chemists and project leaders to track and escort sets of compounds through screening assays
  • Develop and implement assays to measure pre-clinical biomarkers for in vivo efficacy studies
  • Participate in the collaborative evaluation of new technologies
  • Contribute to overall laboratory operations

Requirements

  • BS in Biochemistry or related discipline
  • 5+ years industry experience in running cell-based or enzymatic assays for the purpose of compound evaluation
  • Expert in mammalian cell culture
  • Attention to detail and rigorous observation of variances in methods and results
  • Exceptional written and verbal communication skills and a track record of working well with others
  • Strong computer skills, including Excel, Macros, Graphpad Prism, cloud based software (e.g. CDD and Spotfire)
  • Experienced in the use of radiolabeled tracers and immunological methods in biochemistry
  • Experienced in the use of equilibrium and nonequilibrium radioligand binding assays

Additional Skills and Experience

  • Familiarity with basic statistical analyses and how to apply them to biological data
  • Previous experience working with allosteric modulators and/or GPCR targets

Compensation and Benefits

You will appreciate a competitive compensation package including excellent benefits (medical, dental, vision, 401k, life/disability insurance and more). You will enjoy a challenging work environment, amazing colleagues and the ability to make a difference.

Send your resume to careers@resettherapeutics.com.